Publications

Original Reports:

Knosp CA, Carroll HP, Elliott J, Saunders SP, Nel HJ, Amu S, Pratt JC, Spence S, Doran E, Cooke N, Jackson R, Swift J, Fitzgerald DC, Heaney LG, Fallon PG, Kissenpfennig A, Johnston JA. SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses. J. Exp. Med. 2011; 208 (7) 1523-1531.     http://www.ncbi.nlm.nih.gov/pubmed/21646394

Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ.  IL-3 induced c-Fos activation is modulated by Gab2-calcineurin interaction.  J. Biol. Chem. 2008: 283(35):23505-23509. http://www.jbc.org/cgi/content/full/283/35/23505?view=long&pmid=18586679

Foley CJ, Freedman H, Choo SL, Onyskiw C, Fu NY, Yu VC, Tuszynski J, Pratt JC, Baksh S.  Dynamics of RASSF1A/MOAP-1 Association with Death Receptors.  Mol Cell Biol. 2008; 14:4520-4535. http://mcb.asm.org/cgi/content/full/28/14/4520?view=long&pmid=18474619

Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang YP, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.  Essential role for Gab2 in the allergic response.  Nature 2001; 412:186-190. http://www.nature.com/nature/journal/v412/n6843/full/412186a0.html

Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt M-C, Gundel R, Gelfand EW.  A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13- induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness.  J Immunol. 2001;166:5792-5800. http://www.jimmunol.org/cgi/content/full/166/9/5792

Chayama K, Papst PJ, Garrington TP, Pratt JC, Ishizuka T, Webb S, Ganiatsas S, Zon LI, Sun W, Johnson GL, Gelfand EW.  Role of MEKK2-MEK5 in the regulation of TNF-a gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells.  Proc Natl Acad Sci 2001; 98(8): 4599-4604. http://www.pnas.org/content/98/8/4599

Pratt JC, Igras VE, Maeda H, Baksh S, Gelfand EW, Burakoff SJ, Neel BG, Gu H.  Gab2 mediates an inhibitory phosphatidylinositol 3’ kinase pathway in T cell antigen receptor signaling.  J Immunol 2000; 165(8):4158-63. http://www.jimmunol.org/cgi/content/full/165/8/4158

Dreyfus DH, Nagasawa M, Pratt JC, Kelleher CA, Gelfand EW.  Inactivation of NF-kappaB by EBV BZLF-1 encoded ZEBRA protein in human T cells.  J Immunol 1999; 163(11):6261-6268. http://www.jimmunol.org/cgi/content/full/163/11/6261

Pratt JC, van den Brink MRM, Igras VE, Walk SF, Ravichandran KS, Burakoff SJ.  Requirement for Shc in TCR-mediated activation of a T cell hybridoma.  J Immunol 1999; 163(5):2586-2591. http://www.jimmunol.org/cgi/content/full/163/5/2586

van den Brink MRM, Kapeller R, Pratt JC, Chang, JH, Burakoff SJ.  The extracellular receptor kinase (Erk) pathway is required for activation-induced cell death of T cells.  J Biol Chem 1999; 274(16):11178-11185. http://www.jbc.org/cgi/content/full/274/16/11178

Gu H, Pratt JC, Burakoff SJ, Neel BG  Cloning of p97/Gab2, the major SHP-2 binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.  Mol Cell 1998; 2:729-740. http://www.molecule.org/content/article/abstract?uid=PIIS1097276500802889

Chang JH, Pratt JC, Sawasdikosol S, Kapeller R, Burakoff SJ.  The small GTP-binding protein Rho potentiates AP-1 transcription in T cells.  Mol Cell Biol 1998; 18(9): 4986-4993. http://mcb.asm.org/cgi/content/full/18/9/4986?view=long&pmid=9710582

Ravichandran KS, Zhou MM, Pratt JC, Harlan JE, Walk SF, Fesik SW, Burakoff SJ.  Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine binding domain in vivo.  Mol Cell Biol 1997; 17:5540-5549. http://mcb.asm.org/cgi/reprint/17/9/5540?view=long&pmid=9271429

Sawasdikosol S, Chang JH, Pratt JC, Wolf G, Shoelson S, Burakoff SJ.  Tyrosine phosphorylated Cbl binds to Crk after T cell activation.  J Immunol 1996;157:110-116. http://www.jimmunol.org/cgi/reprint/157/1/110

Pratt JC, Weiss M, Sieff CA, Shoelson SE, Burakoff SJ, Ravichandran KS.  Evidence for a physical association between the Shc-PTB domain and the bc chain of the granulocyte-macrophage colony-stimulating factor receptor.  J Biol Chem 1996;271(21):12137-40. http://www.jbc.org/cgi/content/full/271/21/12137

Tsygankov AY, Ha WK, Pratt JC, Spana C, Class K, Gaulton GN, Kamoun M, Bolen JB.  Diminished tyrosine protein kinase activity in T cells unresponsive to TCR stimulation.  J Leuk Biol 1994;55:289-98. http://www.jleukbio.org/cgi/reprint/55/3/289

Mansur IG, Leca G, Pratt JC, Degos L, Boumsell L, Bensussan A.  Identification of a novel functional 85-kDa glycoprotein restricted to long term dividing human lymphocytic lines.  Human Immunol 1993;37(1):31-8. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T3B-47J6TX5-HB&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a1bb52333c6f1eaaa525ee60648024d0

Pratt JC, Gaulton GN. The role of calcium in activation of T cell phospholipase C.  Allergy and Immunology 1990;9:269-75.

Merida I, Pratt JC, Gaulton GN.  Regulation of interleukin 2-dependent growth responses by glycosylphosphatidylinositol molecules.  Proc Natl Acad Sci, USA 1990;87:9421-5. http://www.pnas.org/content/87/23/9421

Siliciano RF, Hemesath TJ, Pratt JC, Dintzis RZ, Dintzis HM, Acuto O, Shin HSM, Reinherz EL.  Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti heterodimers of MHC-restricted T cell clones. Cell 1986;47:161-71. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-4CB6KJK49&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3c16c682ae689c53a639fc9d48493485

Siliciano RF, Pratt JC, Schmidt RE, Ritz J, Reinherz EL.  Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein. Nature 1985;317:428-30. http://www.ncbi.nlm.nih.gov/pubmed/2864636?ordinalpos=28&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Presentations, Abstracts, Conferences: Olin undergraduates are indicated in Bold font.

Pratt JC.  Hype v. Hope in Medical News. Needham Adult Education. 2017

Pratt, JC and Goodman J. Olin College: A Culture of Curricular Innovation. Olin College Parents’ Weekend. 2016

Pratt, JC. Olin College: A New Model of Engineering Education. UNSW School of Computer Science and Engineering, 2016

Mamula E, Getto RG, Nayback C, Wu AB, Joe I, and Pratt JC. The Tumor Suppressor Protein RASSF1A modulates transcriptional activation of NFAT {Abstract} New England Immunology Conference, 2014.

Pratt JC, Invited panelist. Mass STEM Summit 2014 Higher-Ed Session #1

Massachusetts Integrative Science in Higher Education – What’s Going On in 2014?                       

Getto RG, Nayback CE, WU, AB and  Pratt JC. The tumor suppressor RASSF1A induces transcriptional activation of FasL {Abstract} New England Immunology Conference, 2013.

Genomes, Environment, Traits Conference, Harvard Medical School, invited participant, 2013.

Nayback CE, Getto RG, Wu AB, Barnes CE and Pratt JC.  Apoptosis induction through RASSF1A upregulation of FasL. {Abstract} American Association for the Advancement of Science, 2013.

Perera J, Burger J, Aznavoorian-Cheshire S and Pratt JC.  The role of RASSF1A in FasL expression and function.  {Abstract} American Association of Cancer Researchers, 2012

Genomes, Environment, Traits Conference, Harvard Medical School, invited participant, 2012.

Burger J, Perera J, Aznavoorian-Cheshire S and Pratt JC.  The Role of RASSF1A in Apoptosis of T Lymphocytes {Abstract} Biomedical Engineering Society, 2011.

Sun S, Firstenberg L, Simonovich J, Fox R and Pratt JC. The Effect of RASSF1A on FasL-Mediated Apoptosis in Jurkat T Cells. {Abstract} American Society for Cell Biology, 2010.

Knosp, C, Carroll HP., Pratt JC, Dunne P., Mills K,H., Kissenpfennig, A. and J.A. Johnston  Importance of SOCS2 for T Cell Development and Function. {Abstract} Ulster Immunology Group: Inflammation From Cell to Clinic, 2009.

Baksh S, Laprise S and Pratt JC.  The Function of RASSF1A in T cells. {Abstract} The first international RASSF Symposium, 2009.

Laprise SL, Levi K, Sullivan J, Aznavoorian-Cheshire S, Baksh S and Pratt JC.  Functional interaction between RASSF1A and Grb2. {Abstract} The first international RASSF Symposium, 2009.

Pratt JC and Laprise SL  Functional Effects of RASSF1A. University of Massachusetts, Boston seminar series.  Host:  Dr. Ken Campbell, December 2008.

Baksh, S, Laprise SL and Pratt JC. The Function of RASSF1A in T cells {Abstract} New England Immunology Conference, 2008.

Laprise, SL, Levi K, Sullivan J, Aznavoorian-Cheshire S, Baksh S, Pratt JC. Binding dynamics between the RASSF1A tumor suppressor and Grb2 in the cell death response {Abstract} Society for the Study of Reproduction, 2008.

Levi, K., Baksh S. Pratt JC,  Functional Interaction of RASSF1A and Grb2 with TNFR1 {Abstract} American Society for Cell Biology, 2007.

Sullivan, JL, Baksh S Pratt JC,  RASSF1A Inhibition of Transcription in U2OS Cells, {Abstract} American Society for Cell Biology, 2007.

Miroshnikova YA, Pratt JC, AL. Sieminski.  Role for tumor suppressor, RASSF1A, in cellular response to substrate stiffness {Abstract}  Biomedical Engineering Society. 2007.

Pratt JC.  Changing the face of Science and Engineering.  Smith College, Northampton, MA, April 2006.

Pratt JC, Foley CJ, Baksh S.  Recruitment and activation of RASSF1A by the tumor necrosis factor receptor. {Abstract} The Journal of Immunology supplement. 2006 176:S26.

Pratt JC.  In vivo, in vitro, in silico:  Principles of Modern Biology.  Intel Corp.  Hudson, MA, Dec. 2005.

Zastavker Y, Tilley BS, Pratt JC.  Spiraling into Gallstone Disease:  A Physicist’s Spin on One Digestive Tract Disorder [Abstract] Second IUPAP International Conference on Women in Physics 2005.

Pratt JC.  Managing the Technology Intensive Enterprise (Babson MBA class, Anirudh Dhebar, faculty), guest lecturer (2004).

Tomkinson A, Pratt JC, Duez C, Joetham A, Gundel R, Gelfand EW.  A murine IL-4 antagonist mutant protein inhibits IL-4 and IL-13-induced Stat6 phosphorylation and IgE production [Abstract] Journal of Allergy and Clinical Immunology 2001 107(2); S61 208.

Pratt JC.  The Function of Shc in T lymphocytes.  deCode Genetics Seminar Series, Reykjavik, Iceland. 1999.

van den Brink MRM, Pratt JC, Igras VE, Walk SF, Ravichandran KS, Burakoff SJ.  Requirement for Shc in T cell antigen receptor-mediated activati6on of a T cell hybridoma.  [Abstract] Blood 1999. 94(10) 9A. 23.

Pratt JC, Cai H, Cooper G, Burakoff SJ.  Involvement of protein kinases in the Ras/Raf pathway in human T cells, [Abstract] 9^th Intl Congress Immunol Abs. 1995;685.

Pratt JC, Gaulton GN.  Regulation of T cell phospholipase C by phosphorylation. [Abstract] 8^th Intl Congress of Immunol Abs.1992;361.

Pratt JC, Gaulton GN.  Purification and characterization of PI-PLC from human T lymphocytes. [Abstract]  J Cell Biochem. 1991;15B:142.

Pratt JC. Regulation of phospholipase C activity during T cell activation.  7th International Congress of Immunology. 1990.

Pratt JC.  Purification of PI-PLC in human T lymphocytes.  Southwestern Region Immunology Conference. Philadelphia, PA. 1990.

Pratt JC, Gaulton GN.  Regulation of phospholipase C activity during T cell activation. [Abstract] 7^th Intl Congress of Immunol Abs. 1989;366.

Pratt JC, Stadecker M, Gaulton GN.  Virus binding and modulation of MHC components in thyroid follicular epithelial cells by reovirus type 1.  [Abstract]  J Cell Biochem. 1988;12C:56.

Reviews and Educationally Relevant Publications:

Pratt JC.  Purification and characterization of a phosphatidylinositol-specific phospholipase C from human T lymphocytes [Dissertation].  Philadelphia, Pennsylvania: University of Pennsylvania, 1991. 128 pp.

Pratt JC, Gaulton GN.  T cell activation and signaling. In:  Levinson A, Patterson Y, eds. Molecular and Cellular Biology of the Allergic Immune Response.  New York: Marcel Dekker Publ.  1994:122-143.

Pratt JC, Gaulton GN.  Multifunctional roles of glycosyl-phosphatidylinositol lipids. DNA and Cell Biol.  1994;12(10):861-9. http://www.ncbi.nlm.nih.gov/pubmed/8274219?ordinalpos=23&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Gaulton GN, Pratt JC.  Glycosylated phosphatidylinositol molecules as second messengers.  Seminars in Immunol.  1994;6:97-104. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WX3-45NJFFH-1C&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=76e76aecaa5da13837a366b6fe44ab2c

Ravichandran KS, Pratt JC, Sawasdikosol S, Irie HY, Burakoff SJ.  Coreceptors and adapter proteins in T cell signaling.  Ann NY Acad Sci  1995;766:117-33. http://www3.interscience.wiley.com/journal/119242205/abstract?CRETRY=1&SRETRY=0

Pratt JC, Ravichandran KS, Sawasdikosol S, Chang JH, Burakoff SJ.  Multifunctional roles of adapter proteins in T-cell signaling.  The Immunologist  1996;4(4):122-127.

Pratt JC, Sawasdikosol S, van den Brink MRM, Burakoff SJ.  Positive and negative signaling pathways.  Transplan. Proc.  1999;31(2B):772-774. http://www.ncbi.nlm.nih.gov/pubmed/10083327?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Sawasdikosol S, Pratt JC, Meng W, Eck MJ and Burakoff SJ.  Adapting to multiple personalities:  Cbl is also a RING finger ubiquitin ligase.  BBA–Rev. on Cancer.  2000, 1471(1):M1-M12. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T23-412RFBF-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2afa7d47c5b9a0c598382f2b838b55f1

Somerville M, Anderson D, Berbeco H, Bourne JR, Crisman J, Dabby D, Donis-Keller H, Holt SS, Kerns S, Kerns DV, Martello R, Miller RK, Moody M, Pratt G, Pratt JC, Shea C, Schiffman S, Spence S, Stein LA, Stolk, JD, Storey BD, Tilley B, Vandiver B, Zastavker, Y.  The Olin Curriculum:  Thinking Toward the Future.  IEEE Transactions on Education 2005; 48 (1): 198-205. http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=1393122